Here are three key battles that could decide the outcome of the game.

Mikel Merino vs Micky van de Ven

Mikel Arteta may start Mikel Merino as his striker, given Viktor Gyokeres' injury and Kai Havertz's ongoing recovery. Merino has shown promise as a substitute, scoring a brace against Slavia Prague and assisting in the 2-2 draw with Sunderland.

However, Tottenham's centre-backs, Cristian Romero and Micky van de Ven, are a formidable pair. Van de Ven has been the standout performer, making 13 tackles, winning 34 duels, and making 41 recoveries. He's also a threat going forward, with three league goals already.

Merino's tendency to drop deeper to receive the ball could play into Van de Ven's hands, as the Dutchman is comfortable moving into midfield and recovering quickly.

Declan Rice vs Joao Palhinha

Games like this are often won in midfield, and both teams have strong options in the centre of the park. Declan Rice, however, is one of the best in the league, and Joao Palhinha will face a tough test.

Palhinha has been a revelation since joining Tottenham on loan, leading the way with tackles, duels, and aerial duels. However, he and his partner, Rodrigo Bentancur, tend to play a conservative game, which limits Tottenham's attacking potential.

Palhinha's primary job will be to stop Rice, who is at the heart of everything good happening at Arsenal. Rice has completed 591 passes with a success rate of 90.8%, created 18 chances, and had 16 successful crosses.

Bukayo Saka vs Djed Spence

Bukayo Saka hasn't quite reached his previous heights, but three goals in his last five games suggest he's close to returning to form.

He'll likely face England teammate Djed Spence, who has emerged as a first-team regular for Tottenham. Spence has struggled in some games, but he'll be looking to add another big name to his list of opponents.

Spence will face a tough matchup against Saka, who remains Arsenal's best attacking threat with 17 chances created, 17 successful dribbles, and 12 successful crosses.